How it Works
Research has demonstrated that the ingredients in CRYODERM stimulate
nitric oxide (NO) formation through activation of
Ca2+/calmodulin-dependent protein kinase (CaM kinase). Nitric oxide, in
turn, binds to and activates guanylyl cyclase. This enzyme catalyzes the
dephosphorylation of GTP to cyclic GMP (cGMP), which serves as a second
messenger for signaling smooth muscle relaxation.
NO:
- Direct vasodilation (flow dependent and receptor mediated)
- Indirect vasodilation by inhibiting vasoconstrictor influences (e.g., inhibits angiotensin II and sympathetic vasoconstriction)
- Anti-thrombotic effect - inhibits platelet adhesion to the vascular endothelium
- Anti-inflammatory effect - inhibits leukocyte adhesion to vascular endothelium; scavenges superoxide anion
- Anti-proliferative effect - inhibits smooth muscle hyperplasia
- Scavenges free radicals, improving cellular health
- Inhibits blood clotting (platelet adhesion).
cGMP:
Cyclic GMP induces smooth muscle relaxation by multiple mechanisms including:
- Increased intracellular cGMP, which inhibits calcium entry into the cell, and decreases intracellular calcium concentrations.
- Activates K+ channels, which leads to hyperpolarization and relaxation
- Stimulates a cGMP-dependent protein kinase that activates
myosin light chain phosphatase, the enzyme that dephosphorylates myosin
light chains, which leads to smooth muscle relaxation.
- Induces smooth muscle relaxation
- Inhibits blood clotting (platelet adhesion).
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*ARNICA: Research studies at The
University Of California San Francisco Medical Center showed topical
applications of Arnica to be effective in reducing bruising, swelling,
edema, hematoma and contusions.
*BOSWELLA:
Has Anti-inflammatory and Anti-Arthritic actions in acute and chronic
models of inflammation. Boswella reduces swelling, increasing mobility,
thereby effectively reducing pain.
*EUCALYPTUS: Is a Pain Reliever with warming properties that is also anti-bacterial in nature.
*ILEX: Reduces pain, swelling and loosens stiff joints.
*MENTHOL: Is
used clinically as an anti-inflammatory and Pain Reliever. It causes a
cold sensation on the skin, by activating peripheral cold receptors.
*MSM:
Is a naturally occurring, essential nutrient found in healthy tissue
and joints. Studies at The University of Oregon Medical School reported
that: MSM has a wide range of pharmacologic actions including topical
membrane penetration, anti-inflammation and local analgesia.” Applied
topically MSM creates a tingling sensation.
*PEPPERMINT OIL: Has
anesthetic properties as well as being a vascular and lymphatic system
stimulant. Peppermint creates a burning-cold sensation.
*PURIFIED WATER: Has been processed by reverse osmosis to insure that it is chemical free.
*SD ALCOHOL 39-C: All Natural, Distilled Grain Alcohol. For External Use Only.
See bottle label for complete uses, warnings and directions.
*These Statements Have Not Been Evaluated By The FDA
